Spectrophotometric determination of triclabendazole by acid-dye complexation method in bulk and pharmaceutical formulation

Two simple, accurate and sensitive spectrophotometric methods were developed for the determination of ticlabendazole in bulk and pharmaceutical formulation. These methods were based on the formation of ion-pair association complex (1:1) with bromocresol purple (BCP) and bromophenol blue (BPB). The coloured products were extracted into chloroform and measured spectrophotometrically at 420 nm. Linearity ranges were 20 – 100 μg/ml for BCP and 10 – 100 μg/ml for BPB, the mean percentage recoveries were 99.61±1.152% and 99.60±0.986% for BCP and BPB respectively. Statistical comparison between the results obtained by these methods and the manufacturer’s method was done, and no significance difference was obtained.